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1 Improve Vaccines
2 Create New Vaccines
3 Control Insect Vectors
4 Improve Nutrition
5 Limit Drug Resistance
6 Cure Infection
7 Measure Health Status
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Initiative Selects 43 Groundbreaking Projects
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Dedicated Tuberculosis Gene Expression Database
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Explore the Initiative
Projects by Goal
Projects by Disease
Projects by Technology
1 Improve Vaccines
Challenges
1 Single-Dose Vaccines
Linking Innate and Specific Immunity to Develop Single Dose Vaccines for Neonates
A Live Recombinant Attenuated Salmonella Anti-Pneumococcal Vaccine for Newborns
2 Heat-Stable Vaccines
Thermostable Vaccines with Improved Stability at Non-Refrigerated Temperatures
Increasing Vaccine Stability Through Novel Technology
Bacterial Spores as Vaccine Delivery Systems
3 Needle-Free Delivery
Surface Modified Nanostructures as Delivery Vehicles for Transmucosal Vaccination
Nanoemulsions as Adjuvants for Nasal-Spray Vaccines
Needle-Free Vaccination Via Nanoparticle Aerosols
Needle Free Delivery of Stable Respirable Powder Vaccine
Development of a Targeted Mucosal Vaccine Delivery Technology
2 Create New Vaccines
Challenges
4 Tests for Vaccine Evaluation
Novel Mouse Models for Testing HIV and HCV Vaccines
Development of Novel Mouse Models for HIV and HCV Infection
Attenuated Vaccine Candidates
5 Design Antigens for Protective Immunity
Enhancing the Immunogenicity and Efficacy of Vectored Vaccines
A Protective Genetically Attenuated P. Falciparum Sporozoite Vaccine
Novel Antigen Design and Delivery for Mucosal Protection Against HIV-1 Infection
Improved Vaccine Efficacy via Dendritic Cells and Flavivirus Vectors
6 Learn about Immunological Responses
Protective Immunity Against Severe Malaria in Young Children
Biomarkers of Protective Immunity Against TB in the Context of HIV/AIDS in Africa
Immunity to Prevent Pneumococcal Transmission: Correlates of Protection and Herd Immunity
Learning From the Human Genome How Protective Immunity Against Malaria Works
Comprehensive Studies of Mechanisms of HIV Resistance in Highly Exposed Uninfected Women
Molecular Analysis and Modeling of HIV-1 Transmission, Containment, and Escape
Exploration Topics
Create New Ways To Protect Against Infectious Diseases
3 Control Insect Vectors
Challenges
7 Genetic Strategy
Homing Endonuclease Genes: New Tools for Mosquito Population Engineering and Control
Developing Novel Transgenic Strategies for Introducing Dengue Virus Refractivity in Mosquito Cells and Tissues
Genetic Strategies for Control of Dengue Virus Transmission
Modifying Mosquito Population Age Structure to Eliminate Dengue Transmission
8 Chemical Strategy
Molecular Approaches to Alter Olfactory-Driven Behaviors of Insect Disease Vectors
Molecular Design of Selective Anticholinsterases for Mosquito Control
Disruption of Malaria Transmission by Chemical Manipulation of Anopheline Olfactory Responses
4 Improve Nutrition
Challenges
9 Nutrient-Rich Plants
Nutritionally-Enhanced Sorghum for the Arid and Semi-Arid Tropical Areas of Africa
Improving Rice for High Beta-Carotene, Vitamin E, and Enhanced Iron and Zinc Bioavailability
Development of Bananas with Optimized Bioavailable Micronutrients
Improving Cassava for Nutrition, Health, and Sustainable Development
5 Limit Drug Resistance
Challenges
10 Minimize Resistance
Novel Therapeutics that Boost Innate Immunity to Treat Infectious Diseases
Natural Products Inhibit Intracellular Microorganisms Via Cellular Mechanisms
Exploration Topics
Create Drugs and Delivery Systems to Limit Drug Resistance
6 Cure Infection
Challenges
11 Therapies
Drugs for Treatment of Latent Tuberculosis Infection
12 Immunological Methods
Immunological Strategies for Curing Chronic Hepatitis Virus Infections
Preclinical and Clinical Evaluation of a Post-Exposure TB Vaccine
Engineering Immunity Against HIV and Other Dangerous Pathogens
Novel Therapeutic Vaccines for Acute and Persistent Papillomavirus Infections
Exploration Topics
Create New Ways to Prevent or Cure HIV Infection
Explore The Basis For Latency in TB
7 Measure Health Status
Challenges
13 Population Health
Population Health Metrics Research Consortium Project
14 Diagnostic Tools
Integrated Rapid Test Platforms Appropriate for the Developing World
A Point-of-Care Diagnostic System for the Developing World
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